Inhibition of infection caused by severe acute respiratory syndrome-associated coronavirus by equine neutralizing antibody in aged mice.
Identifieur interne : 003674 ( Main/Exploration ); précédent : 003673; suivant : 003675Inhibition of infection caused by severe acute respiratory syndrome-associated coronavirus by equine neutralizing antibody in aged mice.
Auteurs : Lili Zhou [République populaire de Chine] ; Bing Ni ; Deyan Luo ; Guangyu Zhao ; Zhengcai Jia ; Liangyan Zhang ; Zhihua Lin ; Li Wang ; Songle Zhang ; Li Xing ; Jintao Li ; Yunfei Liang ; Xinfu Shi ; Tingting Zhao ; Liyun Zhou ; Yuzhang Wu ; Xiliang WangSource :
- International immunopharmacology [ 1567-5769 ] ; 2007.
Descripteurs français
- KwdFr :
- Animaux, Anticorps antiviraux (immunologie), Effet cytopathogène viral, Equus caballus, Fragments Fab d'immunoglobuline (immunologie), Modèles animaux de maladie humaine, Souris, Souris de lignée BALB C, Syndrome respiratoire aigu sévère (), Syndrome respiratoire aigu sévère (anatomopathologie), Vieillissement, Virus du SRAS (immunologie).
- MESH :
- anatomopathologie : Syndrome respiratoire aigu sévère.
- immunologie : Anticorps antiviraux, Fragments Fab d'immunoglobuline, Virus du SRAS.
- Animaux, Effet cytopathogène viral, Equus caballus, Modèles animaux de maladie humaine, Souris, Souris de lignée BALB C, Syndrome respiratoire aigu sévère, Vieillissement.
English descriptors
- KwdEn :
- Aging, Animals, Antibodies, Viral (immunology), Cytopathogenic Effect, Viral, Disease Models, Animal, Horses, Immunoglobulin Fab Fragments (immunology), Mice, Mice, Inbred BALB C, SARS Virus (immunology), Severe Acute Respiratory Syndrome (pathology), Severe Acute Respiratory Syndrome (prevention & control).
- MESH :
- chemical , immunology : Antibodies, Viral, Immunoglobulin Fab Fragments.
- immunology : SARS Virus.
- pathology : Severe Acute Respiratory Syndrome.
- prevention & control : Severe Acute Respiratory Syndrome.
- Aging, Animals, Cytopathogenic Effect, Viral, Disease Models, Animal, Horses, Mice, Mice, Inbred BALB C.
Abstract
The high susceptibility of elderly to severe acute respiratory syndrome-associated coronavirus (SARS-CoV) indicates how crucial it is to protect the elderly by various strategies. Aged BALB/c mice displayed a high susceptibility to SARS-CoV and have been a valuable platform for evaluation of strategies against SARS-CoV infection. In this study, we confirmed the validity of this model using various methods, and verified that equine anti-SARS-CoV F(ab')(2) can prevent aged animals from SARS-CoV infection. In a therapeutic setting, treatment with anti-SARS-CoV F(ab')(2) decreased viral load more than several thousand folds in the lungs. Thus, this antibody should be a potential candidate for treatment of elderly patients suffering from SARS.
DOI: 10.1016/j.intimp.2006.10.009
PubMed: 17276898
Affiliations:
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respiratory syndrome-associated coronavirus by equine neutralizing antibody in aged mice.</title><author><name sortKey="Zhou, Lili" sort="Zhou, Lili" uniqKey="Zhou L" first="Lili" last="Zhou">Lili Zhou</name><affiliation wicri:level="1"><nlm:affiliation>Department of Immunology, Institute of Microbiology Epidemiology, Academy of Military Medical Sciences, Beijing 100071, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Immunology, Institute of Microbiology Epidemiology, Academy of Military Medical Sciences, Beijing 100071</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Ni, Bing" sort="Ni, Bing" uniqKey="Ni B" first="Bing" last="Ni">Bing Ni</name></author><author><name sortKey="Luo, Deyan" sort="Luo, Deyan" uniqKey="Luo D" first="Deyan" last="Luo">Deyan Luo</name></author><author><name sortKey="Zhao, Guangyu" sort="Zhao, Guangyu" uniqKey="Zhao G" first="Guangyu" last="Zhao">Guangyu Zhao</name></author><author><name sortKey="Jia, Zhengcai" sort="Jia, Zhengcai" uniqKey="Jia Z" first="Zhengcai" last="Jia">Zhengcai Jia</name></author><author><name sortKey="Zhang, Liangyan" sort="Zhang, Liangyan" uniqKey="Zhang L" first="Liangyan" last="Zhang">Liangyan Zhang</name></author><author><name sortKey="Lin, Zhihua" sort="Lin, Zhihua" uniqKey="Lin Z" first="Zhihua" last="Lin">Zhihua Lin</name></author><author><name sortKey="Wang, Li" sort="Wang, Li" uniqKey="Wang L" first="Li" last="Wang">Li Wang</name></author><author><name sortKey="Zhang, Songle" sort="Zhang, Songle" uniqKey="Zhang S" first="Songle" last="Zhang">Songle Zhang</name></author><author><name sortKey="Xing, Li" sort="Xing, Li" uniqKey="Xing L" first="Li" last="Xing">Li Xing</name></author><author><name sortKey="Li, Jintao" sort="Li, Jintao" uniqKey="Li J" first="Jintao" last="Li">Jintao Li</name></author><author><name sortKey="Liang, Yunfei" sort="Liang, 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scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antibodies, Viral</term><term>Immunoglobulin Fab Fragments</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Anticorps antiviraux</term><term>Fragments Fab d'immunoglobuline</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aging</term><term>Animals</term><term>Cytopathogenic Effect, Viral</term><term>Disease Models, Animal</term><term>Horses</term><term>Mice</term><term>Mice, Inbred BALB C</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Effet cytopathogène viral</term><term>Equus caballus</term><term>Modèles animaux de maladie humaine</term><term>Souris</term><term>Souris de lignée BALB C</term><term>Syndrome respiratoire aigu sévère</term><term>Vieillissement</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The high susceptibility of elderly to severe acute respiratory syndrome-associated coronavirus (SARS-CoV) indicates how crucial it is to protect the elderly by various strategies. Aged BALB/c mice displayed a high susceptibility to SARS-CoV and have been a valuable platform for evaluation of strategies against SARS-CoV infection. In this study, we confirmed the validity of this model using various methods, and verified that equine anti-SARS-CoV F(ab')(2) can prevent aged animals from SARS-CoV infection. In a therapeutic setting, treatment with anti-SARS-CoV F(ab')(2) decreased viral load more than several thousand folds in the lungs. Thus, this antibody should be a potential candidate for treatment of elderly patients suffering from SARS.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country><settlement><li>Pékin</li></settlement></list><tree><noCountry><name sortKey="Jia, Zhengcai" sort="Jia, Zhengcai" uniqKey="Jia Z" first="Zhengcai" last="Jia">Zhengcai Jia</name><name sortKey="Li, Jintao" sort="Li, Jintao" uniqKey="Li J" first="Jintao" last="Li">Jintao Li</name><name sortKey="Liang, Yunfei" sort="Liang, Yunfei" uniqKey="Liang Y" first="Yunfei" last="Liang">Yunfei Liang</name><name sortKey="Lin, Zhihua" sort="Lin, Zhihua" uniqKey="Lin Z" first="Zhihua" last="Lin">Zhihua Lin</name><name sortKey="Luo, Deyan" sort="Luo, Deyan" uniqKey="Luo D" first="Deyan" last="Luo">Deyan Luo</name><name sortKey="Ni, Bing" sort="Ni, Bing" uniqKey="Ni B" first="Bing" last="Ni">Bing Ni</name><name sortKey="Shi, Xinfu" sort="Shi, Xinfu" uniqKey="Shi X" first="Xinfu" last="Shi">Xinfu Shi</name><name sortKey="Wang, Li" sort="Wang, Li" uniqKey="Wang L" first="Li" last="Wang">Li Wang</name><name sortKey="Wang, Xiliang" sort="Wang, Xiliang" uniqKey="Wang X" first="Xiliang" last="Wang">Xiliang Wang</name><name sortKey="Wu, Yuzhang" sort="Wu, Yuzhang" uniqKey="Wu Y" first="Yuzhang" last="Wu">Yuzhang Wu</name><name sortKey="Xing, Li" sort="Xing, Li" uniqKey="Xing L" first="Li" last="Xing">Li Xing</name><name sortKey="Zhang, Liangyan" sort="Zhang, Liangyan" uniqKey="Zhang L" first="Liangyan" last="Zhang">Liangyan Zhang</name><name sortKey="Zhang, Songle" sort="Zhang, Songle" uniqKey="Zhang S" first="Songle" last="Zhang">Songle Zhang</name><name sortKey="Zhao, Guangyu" sort="Zhao, Guangyu" uniqKey="Zhao G" first="Guangyu" last="Zhao">Guangyu Zhao</name><name sortKey="Zhao, Tingting" sort="Zhao, Tingting" uniqKey="Zhao T" first="Tingting" last="Zhao">Tingting Zhao</name><name sortKey="Zhou, Liyun" sort="Zhou, Liyun" uniqKey="Zhou L" first="Liyun" last="Zhou">Liyun Zhou</name></noCountry><country name="République populaire de Chine"><noRegion><name sortKey="Zhou, Lili" sort="Zhou, Lili" uniqKey="Zhou L" first="Lili" last="Zhou">Lili Zhou</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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